Purpose The expression of the neutrophil high-affinity\nFc-gamma receptor (CD64) can be used as a diagnostic\nmarker for bacterial infection and sepsis. The aims of this\nstudy were to determine the diagnostic accuracy of CD64\ncompared to C-reactive protein (CRP) and white blood cell\ncount (WBC) in patients hospitalized with acute exacerbations\nof COPD (AECOPD) and to investigate the kinetics\nof CD64 expression.\nMethods The present study is a prospective, single-centre\nobservation study. Blood samples were collected from\npatients hospitalized with AECOPD at admission and after\n6, 24 and 48 h. Retrospective reviews on the patients�\nmedical records were performed blinded to the CD64\nresults. The CD64 was measured using the Leuko64 kit\nfrom Trillium Diagnostics, LLC (Maine, USA) with the\nCELL-DYN Sapphire Haematology System (Abbott Laboratories,\nIllinois, USA). Diagnostic accuracy of the CD64,\nCRP and WBC was compared using a receiver operating\ncharacteristic (ROC) curve analysis.\nResults A total of 113 patients were included. Thirty-six\npatients (32 %) had pulmonary infiltrate on chest X-ray at\nadmission (PI). The CD64 was higher in samples from\npatients with AECOPD and PI than those without PI at\nadmission (median 1.25 vs. 0.60, p = 0.002) and during\n48 h of follow-up. The area under the ROC curve of CD64,\nCRP and WBC was 0.69, 0.73 and 0.64, respectively,\n(p = 0.42 for the test of difference).\nConclusion Neutrophil CD64 expression has about the\nsame diagnostic accuracy as CRP in diagnosing pneumonia\nin patients hospitalized with AECOPD, but does not add to\nthe diagnostic accuracy of CRP and WBC count.
Loading....